2. Gene
  3. TICRR - TOPBP1 interacting checkpoint and replication regulator Gene

TICRR - TOPBP1 interacting checkpoint and replication regulator Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SLD3; Treslin; C15orf42

Gene ID: 90381 | Gene type: protein coding

About TICRR

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,575,469-89,628,023 (from NCBI)

This gene has 3 transcripts (splice variants) and 196 orthologues. Broad expression in bone marrow (RPKM 1.6), testis (RPKM 1.3) and 20 other tissues.

Summary

Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

TICRR Products(2)

mRNA Protein Name
NM_001308025.1 NP_001294954.1 treslin isoform 1
NM_152259.4 NP_689472.3 treslin isoform 2

TICRR Protein Structure

Treslin_N

Treslin_N: Treslin N-terminus (208 - 1004)

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  • 1910 a.a.
Protein Preferred Names Protein Names

treslin

topBP1-interacting checkpoint and replication regulator

Related Diseases

Diseases Alias
Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type

VEODS

Mrxsveod

Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type

X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14519 TICRR Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TICRR VGNC VGNC:66183
Canis familiaris TICRR VGNC VGNC:47365
Rattus norvegicus TICRR RGD RGD:1308541
Mus musculus TICRR MGD MGI:1924261
Bos taurus TICRR VGNC VGNC:35860
Macaca mulatta TICRR VGNC VGNC:99272