NMI - N-myc and STAT interactor Gene

Homo sapiens

Gene ID: 9111 | Gene type: protein coding

About NMI

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:151,270,470-151,289,668 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in appendix (RPKM 16.7), bone marrow (RPKM 15.4) and 24 other tissues.

Summary

NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in Cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]

NMI Products(1)

mRNA	Protein	Name
NM_004688.3	NP_004679.2	N-myc-interactor

NMI Protein Structure

IFP_35_N

NID

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

N-myc-interactor

Related Diseases

Diseases

Alias

Mouth Disease

Mouth Diseases

Mouth Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101540	NMI 8739	Agonist	99.02%	Unkown
HY-RS09381	NMI Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NMI	VGNC	VGNC:75359
Mus musculus	NMI	MGD	MGI:1928368
Felis catus	NMI	VGNC	VGNC:68505
Canis familiaris	NMI	VGNC	VGNC:43861
Rattus norvegicus	NMI	RGD	RGD:1311721
Bos taurus	NMI	VGNC	VGNC:56132

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