2. Gene
  3. SLC16A3 - solute carrier family 16 member 3 Gene

SLC16A3 - solute carrier family 16 member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MCT3; MCT4; MCT 3; MCT 4; MCT-3; MCT-4

Gene ID: 9123 | Gene type: protein coding

About SLC16A3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,217,934-82,240,086 (from NCBI)

This gene has 19 transcripts (splice variants), 298 orthologues and 13 paralogues. Broad expression in placenta (RPKM 10.2), appendix (RPKM 8.8) and 22 other tissues.

Summary

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked Monocarboxylate Transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

SLC16A3 Products(6)

mRNA Protein Name
NM_001042422.3 NP_001035887.1 monocarboxylate transporter 4
NM_001042423.3 NP_001035888.1 monocarboxylate transporter 4
NM_001206950.2 NP_001193879.1 monocarboxylate transporter 4
NM_001206951.2 NP_001193880.1 monocarboxylate transporter 4
NM_001206952.2 NP_001193881.1 monocarboxylate transporter 4
NM_004207.4 NP_004198.1 monocarboxylate transporter 4

SLC16A3 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (28 - 371)

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  • 465 a.a.
Protein Preferred Names Protein Names

monocarboxylate transporter 4

monocarboxylate transporter 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132301 MSC-4381 Inhibitor 98.11% Unkown
HY-RS13025 SLC16A3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC16A3 MGD MGI:1933438
Canis familiaris SLC16A3 VGNC VGNC:46242
Bos taurus SLC16A3 VGNC VGNC:34689
Macaca mulatta SLC16A3 VGNC VGNC:77397
Rattus norvegicus SLC16A3 RGD RGD:620603
Felis catus SLC16A3 VGNC VGNC:65210