2. Gene
  3. DERL3 - derlin 3 Gene

DERL3 - derlin 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as IZP6; LLN2; C22orf14; derlin-3

Gene ID: 91319 | Gene type: protein coding

About DERL3

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,834,503-23,839,006 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 176 orthologues and 2 paralogues. Broad expression in stomach (RPKM 12.2), duodenum (RPKM 11.1) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

DERL3 Products(4)

mRNA Protein Name
NM_001002862.3 NP_001002862.1 derlin-3 isoform 2
NM_001135751.2 NP_001129223.1 derlin-3 isoform 1
NM_001363072.2 NP_001350001.1 derlin-3 isoform 4
NM_198440.4 NP_940842.2 derlin-3 isoform 3

DERL3 Protein Structure

DER1

DER1: Der1-like family (13 - 202)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

derlin-3

DERtrin 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03701 DERL3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DERL3 VGNC VGNC:71622
Mus musculus DERL3 MGD MGI:1917627
Rattus norvegicus DERL3 RGD RGD:1597373
Bos taurus DERL3 VGNC VGNC:28012
Felis catus DERL3 VGNC VGNC:61450
Canis familiaris DERL3 VGNC VGNC:39904