LRRFIP2 - LRR binding FLII interacting protein 2 Gene

Homo sapiens

Also known as HUFI-2

Gene ID: 9209 | Gene type: protein coding

About LRRFIP2

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,052,626-37,176,360 (from NCBI)

This gene has 20 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 17.9), heart (RPKM 16.5) and 25 other tissues.

Summary

The protein encoded by this gene, along with MyD88, binds to the cytosolic tail of Toll-like Receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the Caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

LRRFIP2 Products(19)

mRNA	Protein	Name
NM_001134369.2	NP_001127841.1	leucine-rich repeat flightless-interacting protein 2 isoform k
NM_001282691.1	NP_001269620.1	leucine-rich repeat flightless-interacting protein 2 isoform d
NM_001348297.1	NP_001335226.1	leucine-rich repeat flightless-interacting protein 2 isoform b
NM_001348298.1	NP_001335227.1	leucine-rich repeat flightless-interacting protein 2 isoform c
NM_001348299.1	NP_001335228.1	leucine-rich repeat flightless-interacting protein 2 isoform e
NM_001348300.1	NP_001335229.1	leucine-rich repeat flightless-interacting protein 2 isoform e
NM_001348301.1	NP_001335230.1	leucine-rich repeat flightless-interacting protein 2 isoform f
NM_001348302.1	NP_001335231.1	leucine-rich repeat flightless-interacting protein 2 isoform f
NM_001348303.1	NP_001335232.1	leucine-rich repeat flightless-interacting protein 2 isoform g
NM_001348304.1	NP_001335233.1	leucine-rich repeat flightless-interacting protein 2 isoform h
NM_001348305.1	NP_001335234.1	leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348306.1	NP_001335235.1	leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348307.1	NP_001335236.1	leucine-rich repeat flightless-interacting protein 2 isoform i
NM_001348308.1	NP_001335237.1	leucine-rich repeat flightless-interacting protein 2 isoform j
NM_001348309.1	NP_001335238.1	leucine-rich repeat flightless-interacting protein 2 isoform j
NM_001348310.1	NP_001335239.1	leucine-rich repeat flightless-interacting protein 2 isoform k
NM_001348311.1	NP_001335240.1	leucine-rich repeat flightless-interacting protein 2 isoform l
NM_006309.4	NP_006300.1	leucine-rich repeat flightless-interacting protein 2 isoform a
NM_017724.2	NP_060194.1	leucine-rich repeat flightless-interacting protein 2 isoform l

LRRFIP2 Protein Structure

LRRFIP

0
200
400
600
721 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat flightless-interacting protein 2

LRR FLII-interacting protein 2

Related Diseases

Diseases

Alias

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07831	LRRFIP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LRRFIP2	VGNC	VGNC:31035
Rattus norvegicus	LRRFIP2	RGD	RGD:1306234
Canis familiaris	LRRFIP2	VGNC	VGNC:42820
Macaca mulatta	LRRFIP2	VGNC	VGNC:74449
Mus musculus	LRRFIP2	MGD	MGI:1918518
Felis catus	LRRFIP2	VGNC	VGNC:68094

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