2. Gene
  3. TIFA - TRAF interacting protein with forkhead associated domain Gene

TIFA - TRAF interacting protein with forkhead associated domain Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as T2BP; T6BP; TIFAA

Gene ID: 92610 | Gene type: protein coding

About TIFA

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:112,274,537-112,285,904 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 11.2), thyroid (RPKM 11.0) and 25 other tissues.

Summary

This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to Bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018]

TIFA Products(1)

mRNA Protein Name
NM_052864.3 NP_443096.1 TRAF-interacting protein with FHA domain-containing protein A

TIFA Protein Structure

FHA

FHA: FHA domain (47 - 120)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

TRAF-interacting protein with FHA domain-containing protein A

TRAF-interacting protein with a forkhead-associated domain

Related Diseases

Diseases Alias
Chronic Gonococcal Salpingitis

Gonococcal Salpingitis
Acute Salpingitis
Chronic Salpingitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147561 ALPK1-IN-1 Inhibitor 99.14% Unkown
HY-RS14521 TIFA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TIFA VGNC VGNC:107474
Rattus norvegicus TIFA RGD RGD:1359151
Mus musculus TIFA MGD MGI:2182965
Canis familiaris TIFA VGNC VGNC:54373
Bos taurus TIFA VGNC VGNC:35862
Macaca mulatta TIFA VGNC VGNC:79179
Macaca fascicularis TIFA NCBI
Others TIFA NCBI