ARRDC1 - arrestin domain containing 1 Gene

Homo sapiens

Gene ID: 92714 | Gene type: protein coding

About ARRDC1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,605,686-137,615,360 (from NCBI)

This gene has 12 transcripts (splice variants), 225 orthologues and 5 paralogues. Ubiquitous expression in stomach (RPKM 15.2), spleen (RPKM 13.5) and 25 other tissues.

Summary

Enables several functions, including Arrestin family protein binding activity; ubiquitin ligase-substrate adaptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular protein metabolic process; extracellular vesicle biogenesis; and negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARRDC1 Products(2)

mRNA	Protein	Name
NM_001317968.2	NP_001304897.1	arrestin domain-containing protein 1 isoform 2
NM_152285.4	NP_689498.1	arrestin domain-containing protein 1 isoform 1

ARRDC1 Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
400
433 a.a.

Protein Preferred Names

Protein Names

arrestin domain-containing protein 1

alpha-arrestin 1

Related Diseases

Diseases

Alias

Methemoglobinemia And Ambiguous Genitalia

METAG	Methemoglobinemia Type Iv
Isolated 17,20-Lyase Deficiency, Pure	Methemoglobinemia Due To Deficiency Of Cytochrome B5
Methemoglobinemia Type 4	Methemoglobinemia Type Iv, Formerly
Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly	Pure Isolated 17,20-Lyase Deficiency
Methemoglobinemia, Type Iv

Kleefstra Syndrome 1

9q Subtelomeric Deletion Syndrome	KLEFS1
Chromosome 9q34.3 Deletion Syndrome	9q- Syndrome
9q34 Deletion Syndrome	Kleefstra Syndrome Due To 9q34 Microdeletion
Kleefstra Syndrome	9q-Syndrome
9qstds	Kleefstra Syndrome Due To 9q Subtelomeric Deletion
Kleefstra Syndrome Due To Del(9)(Q34)	Kleefstra Syndrome Due To Monosomy 9q34
Chromosome 9q Subtelomeric Deletion Syndrome	Kleefstra Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01030	ARRDC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARRDC1	VGNC	VGNC:26171
Mus musculus	ARRDC1	MGD	MGI:2446136
Felis catus	ARRDC1	VGNC	VGNC:59943
Canis familiaris	ARRDC1	VGNC	VGNC:38138
Rattus norvegicus	ARRDC1	RGD	RGD:1309961
Macaca mulatta	ARRDC1	VGNC	VGNC:69920

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