ASIC3 - acid sensing ion channel subunit 3 Gene

Homo sapiens

Also known as ACCN3; TNaC1; DRASIC; SLNAC1

Gene ID: 9311 | Gene type: protein coding

About ASIC3

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,048,292-151,052,756 (from NCBI)

This gene has 9 transcripts (splice variants), 117 orthologues and 8 paralogues. Broad expression in testis (RPKM 3.0), brain (RPKM 2.0) and 20 other tissues.

Summary

This gene encodes a member of the degenerin/epithelial Sodium Channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

ASIC3 Products(3)

mRNA	Protein	Name
NM_004769.4	NP_004760.1	acid-sensing ion channel 3 isoform a
NM_020321.3	NP_064717.1	acid-sensing ion channel 3 isoform b
NM_020322.3	NP_064718.1	acid-sensing ion channel 3 isoform c

ASIC3 Protein Structure

ASC

0
100
200
300
400
500
531 a.a.

Protein Preferred Names

Protein Names

acid-sensing ion channel 3

acid sensing (proton gated) ion channel 3

Related Diseases

Diseases

Alias

Acute Salpingo-Oophoritis

Acute Salpingitis And Oophoritis

Frozen Shoulder

Adhesive Capsulitis Of Shoulder	Bursitis
Adhesions-Capsulitis,Shoulder	Pericapsulitis Of Shoulder
Duplay Bursitis	Adhesive Shoulder Peritendinitis
Subscapular Adhesion	Shoulder Adhesion
Adhesive Enthesopathy Of Shoulder Region	Adhesive Peritendinitis
Adhesive Shoulder Tenosynovitis	Duplay Periarthritis
Adhesive Shoulder Tendinitis

Femoral Cancer

Femoral Neoplasms	Cancer Of The Femur
Femoral Neoplasm	Neoplasm Of Femur

Myofascial Pain Syndrome

Myofascial Pain Syndromes	Myofascial Pain Dysfunction Syndrome
Fibromyalgia

Miliaria Rubra

Miliaria	Prickly Heat
Miliaria Crystallina

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes	Reflex Sympathetic Dystrophy
Crps

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Paroxysmal Extreme Pain Disorder

PEPD	Familial Rectal Pain
Pexpd	Submandibular, Ocular, And Rectal Pain With Flushing
Pain, Submandibular, Ocular, And Rectal, With Flushing	Rectal Pain, Familial
Submandibular, Ocular And Rectal Pain With Flushing	Familial Rectal Syndrome
Frp	Pain Disorder, Paroxysmal, Extreme

Chronic Fatigue Syndrome

Myalgic Encephalomyelitis	Postviral Fatigue Syndrome
Cfs	Myalgic Encephalitis
Encephalomyelitis, Myalgic	Chronic Fatigue
Fatigue Syndrome, Chronic	Benign Myalgic Encephalomyelitis
Akureyri	Akureyri Disease
Cfs - [Chronic Fatigue Syndrome]	Epidemic Neuromyasthenia
Myalgic Encephalomyelitis Syndrome	Me - [Myalgic Encephalomyelitis]
Pvfs - [Postviral Fatigue Syndrome]	Neuromyasthenia
Iceland Disease	Icelandic Disease

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107757	GMQ	Activator	99.69%	Unkown
HY-122135	A-317567	Inhibitor	99.38%	Unkown
HY-131879	NS383		99.83%	Unkown
HY-P1346A	APETx2 TFA	Inhibitor	98.38%	Unkown
HY-P1346	APETx2	Inhibitor	/	Unkown
HY-100939	4-Chlorophenylguanidine hydrochloride	Modulator	99.07%	Unkown
HY-155017	6-Iodoamiloride	Inhibitor	/	Unkown
HY-P1249	Neuropeptide SF(mouse,rat)	Agonist	/	Unkown
HY-P1249A	Neuropeptide SF(mouse,rat) TFA	Agonist	/	Unkown
HY-P1441A	Mambalgin 1 TFA	Inhibitor	/	Unkown
HY-RS01091	ASIC3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ASIC3	VGNC	VGNC:38179
Bos taurus	ASIC3	VGNC	VGNC:26212
Felis catus	ASIC3	VGNC	VGNC:59972
Macaca mulatta	ASIC3	VGNC	VGNC:80797
Rattus norvegicus	ASIC3	RGD	RGD:708578
Mus musculus	ASIC3	MGD	MGI:2159339

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