2. Gene
  3. MED23 - mediator complex subunit 23 Gene

MED23 - mediator complex subunit 23 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SUR2; CRSP3; MRT18; SUR-2; ARC130; CRSP130; CRSP133; DRIP130

Gene ID: 9439 | Gene type: protein coding

About MED23

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,573,966-131,628,313 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 9.5), lymph node (RPKM 8.5) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

MED23 Products(12)

mRNA Protein Name
NM_001270521.2 NP_001257450.1 mediator of RNA polymerase II transcription subunit 23 isoform c
NM_001270522.2 NP_001257451.1 mediator of RNA polymerase II transcription subunit 23 isoform d
NM_001376517.1 NP_001363446.1 mediator of RNA polymerase II transcription subunit 23 isoform e
NM_001376518.1 NP_001363447.1 mediator of RNA polymerase II transcription subunit 23 isoform f
NM_001376519.1 NP_001363448.1 mediator of RNA polymerase II transcription subunit 23 isoform g
NM_001376520.1 NP_001363449.1 mediator of RNA polymerase II transcription subunit 23 isoform h
NM_001376521.1 NP_001363450.1 mediator of RNA polymerase II transcription subunit 23 isoform i
NM_001376522.1 NP_001363451.1 mediator of RNA polymerase II transcription subunit 23 isoform j
NM_001376523.1 NP_001363452.1 mediator of RNA polymerase II transcription subunit 23 isoform k
NM_001376524.1 NP_001363453.1 mediator of RNA polymerase II transcription subunit 23 isoform l
NM_004830.4 NP_004821.2 mediator of RNA polymerase II transcription subunit 23 isoform a
NM_015979.4 NP_057063.2 mediator of RNA polymerase II transcription subunit 23 isoform b

MED23 Protein Structure

Med23

Med23: Mediator complex subunit 23 (1 - 1307)

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  • 1368 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 23

130 kDa transcriptional co-activator

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Recessive 18, With Or Without Epilepsy

Intellectual Developmental Disorder, Autosomal Recessive 18

MRT18

Mental Retardation, Autosomal Recessive 18

Autosomal Recessive Intellectual Developmental Disorder 18

Mental Retardation, Autosomal Recessive, Type 18
Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Intellectual Disability-18
Argininemia

Hyperargininemia

Arginase Deficiency

Arg1 Deficiency

Arginase-1 Deficiency

Deficiency Of Canavanase

Arginase Deficiency Disease

ARGIN
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type

Methylcobalamin Deficiency, Cblg Type

HMAG

Methionine Synthase Deficiency

Methylcobalamin Deficiency Type Cblg

Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism, Cblg Complementation Type

Homocystinuria-Megaloblastic Anemia Cblg Type

Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cblg Complementation Type

Methylcobalamin Deficiency Cbl G Type

Homocystinuria Due To Defect In Methylation Cbl G

Cblg

Functional Methionine Synthase Deficiency Type Cblg

Methylcobalamin Deficiency Cblg Type

Arakawa Syndrome 2
Opitz-Kaveggia Syndrome

Fg Syndrome

Fgs1

Fgs

Keller Syndrome

OKS

Fg Syndrome 1

Fg Syndrome Type 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-158005 Anticancer agent 195 Inducer / Unkown
HY-RS08294 MED23 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MED23 VGNC VGNC:43131
Bos taurus MED23 VGNC VGNC:31360
Mus musculus MED23 MGD MGI:1917458
Rattus norvegicus MED23 RGD RGD:1307671
Macaca mulatta MED23 VGNC VGNC:74562
Felis catus MED23 VGNC VGNC:102459