AKAP6 - A-kinase anchoring protein 6 Gene

Homo sapiens

Also known as ADAP6; PRKA6; mAKAP; ADAP100; AKAP100

Gene ID: 9472 | Gene type: protein coding

About AKAP6

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:32,329,298-32,837,684 (from NCBI)

This gene has 15 transcripts (splice variants), 204 orthologues and 1 paralogue. Biased expression in brain (RPKM 9.8), heart (RPKM 7.6) and 12 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]

AKAP6 Products(1)

mRNA	Protein	Name
NM_004274.5	NP_004265.3	A-kinase anchor protein 6

Protein Preferred Names

Protein Names

A-kinase anchor protein 6

A kinase (PRKA) anchor protein 6

Related Diseases

Diseases

Alias

Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

Catecholaminergic Polymorphic Ventricular Tachycardia 2	CPVT2
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Ventricular Tachycardia, Stress-Induced Polymorphic
Cvpt2	Double Tachycardia Induced By Catecholamines
Malignant Paroxysmal Ventricular Tachycardia	Multifocal Ventricular Premature Beats
Paroxysmal Ventricular Fibrillation	Syncopal Paroxysmal Tachycardia
Syncopal Tachyarythmia	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1	Multifocal Pvcs
Multifocal Premature Ventricular Beats	Paroxysmal Familial Ventricular Fibrillation

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

Catecholaminergic Polymorphic Ventricular Tachycardia 1	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
CPVT1	Ventricular Tachycardia, Stress-Induced Polymorphic
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Cvpt1
Double Tachycardia Induced By Catecholamines	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Paroxysmal Ventricular Fibrillation
Syncopal Paroxysmal Tachycardia	Syncopal Tachyarythmia
Ventricular Tachycardia Catecholaminergic Polymorphic 1	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1
Multifocal Pvcs	Multifocal Premature Ventricular Beats
Paroxysmal Familial Ventricular Fibrillation	Catecholaminergic Polymorphic Ventricular Tachycardia Type 1

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00521	AKAP6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AKAP6	VGNC	VGNC:25787
Macaca mulatta	AKAP6	VGNC	VGNC:69771
Canis familiaris	AKAP6	VGNC	VGNC:37759
Mus musculus	AKAP6	MGD	MGI:3050566
Felis catus	AKAP6	VGNC	VGNC:59716
Rattus norvegicus	AKAP6	RGD	RGD:69412

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