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  3. TBPL1 - TATA-box binding protein like 1 Gene

TBPL1 - TATA-box binding protein like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620

Gene ID: 9519 | Gene type: protein coding

About TBPL1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:133,952,174-133,990,432 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and 2 paralogues. Broad expression in testis (RPKM 58.3), bone marrow (RPKM 8.1) and 20 other tissues.

Summary

This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]

TBPL1 Products(2)

mRNA Protein Name
NM_001253676.2 NP_001240605.1 TATA box-binding protein-like 1
NM_004865.4 NP_004856.1 TATA box-binding protein-like 1

TBPL1 Protein Structure

TBP

TBP: Transcription factor TFIID (or TATA-binding protein, TBP) (10 - 92)

TBP

TBP: Transcription factor TFIID (or TATA-binding protein, TBP) (97 - 180)

  • 0
  • 100
  • 186 a.a.
Protein Preferred Names Protein Names

TATA box-binding protein-like 1

21-kDA TBP-like protein

Related Diseases

Diseases Alias
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Kummell'S Disease

Traumatic Spondylopathy

Kummell Disease

Kummell'S Spondylitis

Kümmelll-Verneuil Disease

Kümmell Spondylitis

Kümmell Disease

Traumatic Spondylosis
Sleeping Sickness

African Trypanosomiasis

African Sleeping Sickness

Trypanosomiasis, Human East-African

Trypanosomiasis, East African

Trypanosomiasis African

Trypanosomiasis, African

Human African Trypanosomiasis
Infertility
Myofascial Pain Syndrome

Myofascial Pain Syndromes

Myofascial Pain Dysfunction Syndrome

Fibromyalgia
Spondylolisthesis

Slipped Vertebrae

Acquired Spondylolisthesis
Trypanosomiasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14267 TBPL1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TBPL1 MGD MGI:1339946
Bos taurus TBPL1 VGNC VGNC:35660
Felis catus TBPL1 VGNC VGNC:102532
Macaca mulatta TBPL1 VGNC VGNC:83491
Rattus norvegicus TBPL1 RGD RGD:1597456