RNF7 - ring finger protein 7 Gene

Homo sapiens

Also known as SAG; ROC2; rbx2; CKBBP1

Gene ID: 9616 | Gene type: protein coding

About RNF7

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:141,738,298-141,747,560 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.8), adrenal (RPKM 15.8) and 25 other tissues.

Summary

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, Casein Kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF7 Products(3)

mRNA	Protein	Name
NM_001201370.2	NP_001188299.1	RING-box protein 2 isoform 4
NM_014245.5	NP_055060.1	RING-box protein 2 isoform 1
NM_183237.3	NP_899060.1	RING-box protein 2 isoform 3

RNF7 Protein Structure

zf-rbx1

0
100
113 a.a.

Protein Preferred Names

Protein Names

RING-box protein 2

CKII beta-binding protein 1

Related Diseases

Diseases

Alias

Brachydactyly, Type E2

Brachydactyly Type E2	BDE2
Brachydactyly E2

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12096	RNF7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF7	MGD	MGI:1337096
Canis familiaris	RNF7	VGNC	VGNC:45675
Macaca mulatta	RNF7	VGNC	VGNC:76707
Bos taurus	RNF7	VGNC	VGNC:34072
Felis catus	RNF7	VGNC	VGNC:102814
Rattus norvegicus	RNF7	RGD	RGD:1311048