2. Gene
  3. ARHGAP44 - Rho GTPase activating protein 44 Gene

ARHGAP44 - Rho GTPase activating protein 44 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RICH2; NPC-A-10

Gene ID: 9912 | Gene type: protein coding

About ARHGAP44

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:12,789,498-12,991,643 (from NCBI)

This gene has 11 transcripts (splice variants), 269 orthologues and 2 paralogues. Broad expression in brain (RPKM 18.3), colon (RPKM 17.1) and 20 other tissues.

Summary

Enables phospholipid binding activity. Predicted to be involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP44 Products(5)

mRNA Protein Name
NM_001321164.2 NP_001308093.1 rho GTPase-activating protein 44 isoform 2
NM_001321166.2 NP_001308095.1 rho GTPase-activating protein 44 isoform 3
NM_001321167.2 NP_001308096.1 rho GTPase-activating protein 44 isoform 4
NM_001321168.2 NP_001308097.1 rho GTPase-activating protein 44 isoform 5
NM_014859.6 NP_055674.4 rho GTPase-activating protein 44 isoform 1

ARHGAP44 Protein Structure

BAR

BAR: BAR domain (1 - 241)

RhoGAP

RhoGAP: RhoGAP domain (271 - 415)

  • 0
  • 200
  • 400
  • 600
  • 818 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 44

Rho-type GTPase-activating protein RICH2

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Diseases Alias
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Lymphoplasmacytic Lymphoma

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Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00937 ARHGAP44 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGAP44 RGD RGD:1305664
Canis familiaris ARHGAP44 VGNC VGNC:38065
Felis catus ARHGAP44 VGNC VGNC:59893
Bos taurus ARHGAP44 VGNC VGNC:26097
Mus musculus ARHGAP44 MGD MGI:2144423
Macaca mulatta ARHGAP44 VGNC VGNC:99117