hCAI/II-IN-8 

hCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC₅₀ = 21.35 ± 0.39 nM (hCA I); 7.12 ± 0.12 nM (hCA II)). hCAI/II-IN-8 inhibits AChE and BChE as well(IC₅₀ = 46.27 ±0.75 nM (AChE); 43.38 ± 0.83 nM (BChE)). ^[1].^[1].

hCAI/II-IN-8 is an efficient activity inhibitor by forming multiple hydrogen bonds and hydrophobic interactions with key residues in hCA I and hCA II. hCAI/II-IN-8 also has high stability in binding to the enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

388.42

C₂₂H₂₀N₄O₃

CN(C)C1=CC=C(C(OC2=CC=C(/C=N/NC(C3=CN=CC=C3)=O)C=C2)=O)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Çakmak, R.et al. Synthesis of Novel Hydrazide–Hydrazone Compounds and In Vitro and In Silico Investigation of Their Biological Activities against AChE, BChE, and hCA I and II. ACS Omega, 9(18), 20030–20041.