1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. hCAIX/XII-IN-6

hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA).

For research use only. We do not sell to patients.

hCAIX/XII-IN-6 Chemical Structure

hCAIX/XII-IN-6 Chemical Structure

CAS No. : 3031666-31-3

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Description

hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA)[1].

IC50 & Target[1]

hCA II

2950 nM (Ki)

hCA IX

4.1 nM (Ki)

hCA XII

7.7 nM (Ki)

In Vitro

hCAIX/XII-IN-6 has inhibition activitr for human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively[1][1].
hCAIX/XII-IN-6 (150 μM) exhibits a weaker H2S releas[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

hCAIX/XII-IN-6 (oral; 1, 10, 30 mg/kg; single) completely reverts the pain state 45 min after administration and enhances antihyperalgesic effect in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: adjuvant-induced arthritis rat model[1]
Dosage: 1, 10, 30 mg/kg
Administration: oral, single
Result: Evoked an antihypersensitivity effect in a dose-dependent manner.
Reduced spontaneous pain in a dose-dependent manner with a peak of efficacy between 30 and 45 min.
Molecular Weight

601.74

Formula

C26H23N3O6S4

CAS No.
SMILES

O=C(N(CC1=CC=C([N+]([O-])=O)C=C1OC)CCC2=CC=C(S(=O)(N)=O)C=C2)C3=CC=C(C4=CSSC4=S)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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hCAIX/XII-IN-6 Related Classifications

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Product Name:
hCAIX/XII-IN-6
Cat. No.:
HY-151472
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