1. Anti-infection
  2. Virus Protease
  3. HCVcc-IN-1

HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity.

For research use only. We do not sell to patients.

HCVcc-IN-1 Chemical Structure

HCVcc-IN-1 Chemical Structure

CAS No. : 2977251-08-2

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Description

HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity[1].

In Vitro

HCVcc-IN-1 (compound 8c) (0.1, 1, 10, and 100 μg/mL; 1 h) shows antiviral activities against a variety of viruses such as coxsackievirus B4 (CBV4), hepatitis A virus HM 175 (HAV), hepatitis C genotype 4 (HCVcc), adenovirus type 7 (HAdV7), and herpes simplex virus 1 (HSV-1) with viral reduction rates of 86.7%, 66.7%, 23.3%, 66.7%, and 36.7%, respectively[1].
HCVcc-IN-1 (0.57-2.0 μg/mL; 1 h) inhibits various virus with IC50 of 0.57 μg/mL (herpes simplex virus), 0.71 μg/mL (HCVcc genotype virus), and 0.69 μg/mL (coxsackievirus B4), respectively; or with CC50 of 2.0 μg/mL (herpes simplex virus), 1.7 μg/mL (HCVcc genotype virus), and 1.7 μg/mL (coxsackievirus B4), respectively[1].
HCVcc-IN-1 (5.16-7.23 μg/mL) inhibits hepatitis C virus NS3/4A and HSV-USP7 protease enzyme with IC50s of 5.16 μg/mL and 7.23 μg/mL[1].
HCVcc-IN-1 (0.01 mM; 24 h) has low cytotoxicity against FRHK-4, Hep2, BGM, Vero, and Huh 7.5 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: FRHK-4, Hep2, BGM, Vero, and Huh 7.5 cell lines
Concentration: 100 μg/mL
Incubation Time: 24 hours
Result: Showed nontoxic under the doses of 100 μg/mL against FRHK-4, Hep2, BGM, Vero, and Huh 7.5 cells, respectively.
Molecular Weight

705.62

Formula

C29H25BrN2O8S3

CAS No.
SMILES

O=C(C1=C(N)C(C2=NC3=CC=CC=C3S2)=C(S[C@H]4[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@](OC(C)=O)([H])CO4)S1)C5=CC=C(Br)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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HCVcc-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HCVcc-IN-1
Cat. No.:
HY-151581
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