1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Heme Oxygenase-1-IN-1

Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research.

For research use only. We do not sell to patients.

Heme Oxygenase-1-IN-1 Chemical Structure

Heme Oxygenase-1-IN-1 Chemical Structure

CAS No. : 1093058-52-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 365 In-stock
Solution
10 mM * 1 mL in DMSO USD 365 In-stock
Solid
1 mg USD 119 In-stock
5 mg USD 250 In-stock
10 mg USD 450 In-stock
50 mg USD 1400 In-stock
100 mg USD 2100 In-stock
200 mg   Get quote  
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Heme Oxygenase-1-IN-1:

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Description

Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research[1].

IC50 & Target

IC50: 0.25 μM (HO-1)[1]

In Vitro

Heme Oxygenase-1-IN-1 (0-10 µM) attenuates Dipeptidyl peptidase-4 inhibitors (DPP-4i)-induced NF-кB activation in 4T1 cells[2].
Heme Oxygenase-1-IN-1 (0-10 µM) significantly decreases GC cell migration and invasion in parental gastric cancer cells[3].
Heme Oxygenase-1-IN-1 significantly down-regulates HO-1 mRNA level and metastasis-associated gene expressions in GRIM-19-deficient gastric cancer cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

279.18

Formula

C13H15BrN2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

BrC1=CC=C(CCCCN2C=CN=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (447.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5819 mL 17.9096 mL 35.8192 mL
5 mM 0.7164 mL 3.5819 mL 7.1638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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C2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5819 mL 17.9096 mL 35.8192 mL 89.5480 mL
5 mM 0.7164 mL 3.5819 mL 7.1638 mL 17.9096 mL
10 mM 0.3582 mL 1.7910 mL 3.5819 mL 8.9548 mL
15 mM 0.2388 mL 1.1940 mL 2.3879 mL 5.9699 mL
20 mM 0.1791 mL 0.8955 mL 1.7910 mL 4.4774 mL
25 mM 0.1433 mL 0.7164 mL 1.4328 mL 3.5819 mL
30 mM 0.1194 mL 0.5970 mL 1.1940 mL 2.9849 mL
40 mM 0.0895 mL 0.4477 mL 0.8955 mL 2.2387 mL
50 mM 0.0716 mL 0.3582 mL 0.7164 mL 1.7910 mL
60 mM 0.0597 mL 0.2985 mL 0.5970 mL 1.4925 mL
80 mM 0.0448 mL 0.2239 mL 0.4477 mL 1.1193 mL
100 mM 0.0358 mL 0.1791 mL 0.3582 mL 0.8955 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Heme Oxygenase-1-IN-1
Cat. No.:
HY-111798
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