2. MAPK/ERK Pathway Immunology/Inflammation
  3. MAP4K Interleukin Related IFNAR
  4. HPK1-IN-43

HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ). HPK1-IN-43 can be used in cancer research.

For research use only. We do not sell to patients.

HPK1-IN-43 Chemical Structure

HPK1-IN-43 Chemical Structure

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HPK1-IN-43 Related Antibodies

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Description

HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ). HPK1-IN-43 can be used in cancer research[1].

IC50 & Target

HPK1

0.32 nM (IC50)

SLP-76

 

IL-2

 

IFN-γ

 

In Vitro

HPK1-IN-43 (compound 9f) (0-100 nM, 1-18 h) inhibits phosphorylation of SLP76 in Jurkat and primary peripheral blood mononuclear cells (PBMC), with IC50 values of 147.9 nM and 131.8 nM, respectively. HPK1-IN-43 promotes IL-2 and IFN-γ production in PBMCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HPK1-IN-43 Related Antibodies
Molecular Weight

510.51

Formula

C26H25F3N6O2
SMILES

O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=NC(NC4=C(OC)C=C(CCN(C)C5)C5=C4)=NC=C3C(N)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HPK1-IN-43 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-43MAP4KInterleukin RelatedIFNARMAPK Kinase Kinase KinaseILInterferon-α/β receptorInterferon-alpha/beta receptorPBMC cellhuman T lymphocytic leukemia Jurkat cellscancerInhibitorinhibitorinhibit

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HPK1-IN-43
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HY-161335
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