Human enteropeptidase-IN-1 

Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research^[1].

IC_50(initial): 20 nM (enteropeptidase)^[1]
IC_50(app): 1.2 nM (enteropeptidase)^[1]

Human enteropeptidase-IN-1 (compound 6b) has inhibitory activity against enteropeptidase with IC_50(initial)* of 20 nM and IC_50(app)** of 1.2 nM^[1].
_{(*IC50(initial) refers to the inhibitory activity of human enteropeptidase after 6 min of incubation with the enzyme, substrate, and compound.)
(**IC50(app) refers to the apparent IC50 value after 120 min of incubation with the enzyme, substrate, and compound.)}

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

426.38

C₂₀H₁₈N₄O₇

1802891-20-8

OC(C[C@]1(CC(C2=CC(OC(C3=CC=C(C=C3)NC(N)=N)=O)=CC=C2)=NO1)C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ikeda Z, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity. J Med Chem. 2022 Jun 23;65(12):8456-8477.  [Content Brief]