I942

Cat. No.: HY-129738 Purity: 99.38%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

I942 is a first in class, selective non-cyclic nucleotide (NCN) EPAC1 agonist. I942 can attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases.

For research use only. We do not sell to patients.

I942 Chemical Structure

CAS No. : 868145-09-9

Size	Price	Stock	Quantity
5 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 470	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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References
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Description

I942 is a first in class, selective non-cyclic nucleotide (NCN) EPAC1 agonist. I942 can attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases^[1].

IC₅₀ & Target

EPAC1^[1]

Molecular Weight

369.43

Formula

C₂₀H₁₉NO₄S

CAS No.

868145-09-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(NS(=O)(C1=CC=C(C)C=C1C)=O)COC2=CC=C3C=CC=CC3=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (676.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7069 mL	13.5344 mL	27.0687 mL
5 mM	0.5414 mL	2.7069 mL	5.4137 mL
10 mM	0.2707 mL	1.3534 mL	2.7069 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.38%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (247 KB) HNMR (254 KB) LCMS (85 KB)

Handling Instructions (2659 KB)

References

[1]. Graeme Barker, et al. The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation. J Cardiovasc Dev Dis. 2017 Dec 5;4(4):22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7069 mL	13.5344 mL	27.0687 mL	67.6718 mL
	5 mM	0.5414 mL	2.7069 mL	5.4137 mL	13.5344 mL
	10 mM	0.2707 mL	1.3534 mL	2.7069 mL	6.7672 mL
	15 mM	0.1805 mL	0.9023 mL	1.8046 mL	4.5115 mL
	20 mM	0.1353 mL	0.6767 mL	1.3534 mL	3.3836 mL
	25 mM	0.1083 mL	0.5414 mL	1.0827 mL	2.7069 mL
	30 mM	0.0902 mL	0.4511 mL	0.9023 mL	2.2557 mL
	40 mM	0.0677 mL	0.3384 mL	0.6767 mL	1.6918 mL
	50 mM	0.0541 mL	0.2707 mL	0.5414 mL	1.3534 mL
	60 mM	0.0451 mL	0.2256 mL	0.4511 mL	1.1279 mL
	80 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8459 mL
	100 mM	0.0271 mL	0.1353 mL	0.2707 mL	0.6767 mL

I942 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

I942868145-09-9I 942I-942OthersEPAC1 AgonistCardiovascular DiseaseInhibitorinhibitorinhibit

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