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  4. Importin β1-IN-1

Importin β1-IN-1 (compound DD1-Br) is an orally active Importin β1 inhibitor (KD = 0.219 μM). Importin β1-IN-1 exhibits antiproliferative activity on castration-resistant prostate cancer (CRPC) cells. Importin β1-IN-1 alone or in combination with enzalutamide completely prevented tumor growth in a mouse model of drug-resistant CRPC. Importin β1-IN-1 can be used in cancer research.

For research use only. We do not sell to patients.

Importin β1-IN-1 Chemical Structure

Importin β1-IN-1 Chemical Structure

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Importin β1-IN-1 Related Antibodies

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Description

Importin β1-IN-1 (compound DD1-Br) is an orally active Importin β1 inhibitor (KD = 0.219 μM). Importin β1-IN-1 exhibits antiproliferative activity on castration-resistant prostate cancer (CRPC) cells. Importin β1-IN-1 alone or in combination with enzalutamide completely prevented tumor growth in a mouse model of drug-resistant CRPC. Importin β1-IN-1 can be used in cancer research[1].

Molecular Weight

683.54

Formula

C34H35BrO10
SMILES

CC1=C[C@@]2([H])[C@]3(OC(O4)(C5=CC=CC=C5)O6)[C@@]([C@@H]6[C@]4(C(C)=C)[C@H](OC(C7=CC=CC=C7)=O)[C@H]3C)([H])[C@H](O)[C@](Br)(CO)[C@@H](O)[C@]2(O)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Importin β1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Importin β1-IN-1OthersCRPCAR-V7cancertumor22Rv1proliferationInhibitorinhibitorinhibit

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