Isodispar B

Cat. No.: HY-N10304: FAQs
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Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines.

For research use only. We do not sell to patients.

Isodispar B Chemical Structure

CAS No. : 98192-64-4

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Description

In Vitro

Isodispar B (compound 1) (0-100 μM; 72 h) exerts a broad spectrum of anti-cancer activity to inhibit cell proliferation with IC₅₀s of 3.84-56.73 μM^[1].
Isodispar B (1 μM and 10 μM; 3 d) induces apoptosis on nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1) and noncancerous nasopharyngeal cells (NP460)
Concentration:	0-100 μM
Incubation Time:	72 hours
Result:	Showed cytotoxicity and inhibited cell viability with IC50s of 3.84 μM (SUNE1), 11.49 μM (TW01), 9.74 μM (CNE1), 5.58 μM (HK1), 56.73 μM (HCC38), 52.69 μM (MDA-MB-231), 52.75 μM (MDA-ME-468), and 54.85 μM (SKBR3), respectively.

Molecular Weight

338.35

Formula

C₂₀H₁₈O₅

CAS No.

98192-64-4

SMILES

O=C1C=C(C2=CC=CC=C2)C3=C(O)C=C(O)C(C(CC(C)C)=O)=C3O1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lim C K, et al. In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species[J]. Medicinal Chemistry Research, 2016, 25(8): 1686-1694.

Isodispar B Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isodispar B98192-64-4ApoptosisInhibitorinhibitorinhibit

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