2. Neuronal Signaling
  3. Dopamine Transporter
  4. JJC8-088

JJC8-088 is a potent inhibitor of DAT. JJC8-088 is a novel Modafinil-derived ligands. JJC8-088 can be used to study psychostimulant use disorders.

For research use only. We do not sell to patients.

JJC8-088 Chemical Structure

JJC8-088 Chemical Structure

CAS No. : 1627576-82-2

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JJC8-088 Related Antibodies

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Description

JJC8-088 is a potent inhibitor of DAT. JJC8-088 is a novel Modafinil-derived ligands. JJC8-088 can be used to study psychostimulant use disorders[1].

IC50 & Target

DAT

2.53 nM (Ki)

In Vivo

JJC8-088 (3-30 mg/kg, i.p., 30/120 min) can effectively reduce the compulsive self-administration of methamphetamine in rats and increase the amount of exercise[1].
JJC8-088 (0-30 mg/kg, i.p., 30 min prior to testing) can cause a large and rapid increase in extracellular Dopamine (DA) (HY-B0451) levels in rats with history of Cocaine self-administration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: METH addict male Wistar rats (6-8 weeks old; weighing 200-250 g)[1]
Dosage: 0/3/10/30 mg/kg
Administration: i.p.
Result: The half-life of JJC8-088 is 39 min.
Presented low levels in both brain and plasma.
Molecular Weight

498.63

Formula

C28H32F2N2O2S
CAS No.
SMILES

O=S(C(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F)CCN3CCN(CC3)CC(CC4=CC=CC=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JJC8-088 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JJC8-0881627576-82-2Dopamine TransporterDATSLC6A3hERGpsychostimulant use disordersPSUDInhibitorinhibitorinhibit

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HY-158013
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