2. Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. HDAC Apoptosis Histone Demethylase
  4. JMJD3/HDAC-IN-1

JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HADC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion.

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JMJD3/HDAC-IN-1 Chemical Structure

JMJD3/HDAC-IN-1 Chemical Structure

CAS No. : 2883046-06-6

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JMJD3/HDAC-IN-1 Related Antibodies

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Description

JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HADC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].

IC50 & Target

IC50: 16 nM (HDAC1), 534 nM (HDAC6)[1]
Molecular Weight

398.50

Formula

C21H30N6O2
CAS No.
SMILES

O=C(CCCCCNC1=NC(C2=NC=CC=C2)=NC(N3CCCCCC3)=C1)NO
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JMJD3/HDAC-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMJD3/HDAC-IN-12883046-06-6HDACApoptosisHistone DemethylaseHistone deacetylasesAntitumorDual inhibitorJMJD3Structure activity relationship analysisInhibitorinhibitorinhibit

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