KAAD-Cyclopamine (Synonyms: Cyclopamine-KAAD)

Cat. No.: HY-100535 Purity: ≥96.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist.

For research use only. We do not sell to patients.

KAAD-Cyclopamine Chemical Structure

CAS No. : 306387-90-6

Size	Price	Stock	Quantity
25 μg	USD 170	In-stock	Estimated Time of Arrival: December 31
50 μg	USD 270	In-stock	Estimated Time of Arrival: December 31

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Description

KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist^[1].

In Vitro

KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC₅₀ of 3 nM, wheras this cyclopamine derivative has an IC₅₀ of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

697.99

Formula

C₄₄H₆₃N₃O₄

CAS No.

306387-90-6

Appearance

Solid

Color

White to light yellow

SMILES

C[C@H]([C@@](N1CCNC(CCCCCNC(CCC2=CC=CC=C2)=O)=O)([H])[C@](C[C@H](C)C1)([H])O3)[C@@]43C(C)=C(C[C@@]5([H])[C@@]6([H])CC=C(C7)[C@@]5(CCC7=O)C)[C@@]6([H])CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (7.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4327 mL	7.1634 mL	14.3269 mL
5 mM	0.2865 mL	1.4327 mL	2.8654 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥96.0%

Select Batch:

Data Sheet (240 KB) SDS (251 KB)

COA (246 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4327 mL	7.1634 mL	14.3269 mL	35.8171 mL
DMSO	5 mM	0.2865 mL	1.4327 mL	2.8654 mL	7.1634 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KAAD-Cyclopamine306387-90-6Cyclopamine-KAADInhibitorinhibitorinhibit

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