2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. L-817818

L-817818 is a potent and subtype-selective agonist of the somatostatin receptor. L-817818 provides a direct approach to defining somatostatin receptor physiological functions

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L-817818 Chemical Structure

L-817818 Chemical Structure

CAS No. : 217480-27-8

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Based on 1 publication(s) in Google Scholar

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Description

L-817818 is a potent and subtype-selective agonist of the somatostatin receptor. L-817818 provides a direct approach to defining somatostatin receptor physiological functions[1]

Molecular Weight

536.66

Formula

C33H36N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](N)COC([C@@H](CCCCN)NC(CC1=C(C2=CC3=C(C=CC=C3)C=C2)NC4=C1C=CC5=CC=CC=C45)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 54 mg/mL (100.62 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8634 mL 9.3169 mL 18.6338 mL
5 mM 0.3727 mL 1.8634 mL 3.7268 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8634 mL 9.3169 mL 18.6338 mL 46.5844 mL
5 mM 0.3727 mL 1.8634 mL 3.7268 mL 9.3169 mL
10 mM 0.1863 mL 0.9317 mL 1.8634 mL 4.6584 mL
15 mM 0.1242 mL 0.6211 mL 1.2423 mL 3.1056 mL
20 mM 0.0932 mL 0.4658 mL 0.9317 mL 2.3292 mL
25 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.8634 mL
30 mM 0.0621 mL 0.3106 mL 0.6211 mL 1.5528 mL
40 mM 0.0466 mL 0.2329 mL 0.4658 mL 1.1646 mL
50 mM 0.0373 mL 0.1863 mL 0.3727 mL 0.9317 mL
60 mM 0.0311 mL 0.1553 mL 0.3106 mL 0.7764 mL
80 mM 0.0233 mL 0.1165 mL 0.2329 mL 0.5823 mL
100 mM 0.0186 mL 0.0932 mL 0.1863 mL 0.4658 mL
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L-817818 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-817818217480-27-8L817818L 817818Somatostatin ReceptorSSTRsSSTRsubtype-selectivesomatostatin receptorphysiological functionsInhibitorinhibitorinhibit

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