2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Phosphatase Reactive Oxygen Species Endogenous Metabolite
  4. L-Ascorbic acid 2-phosphate magnesium

L-Ascorbic acid 2-phosphate magnesium  (Synonyms: 2-Phospho-L-ascorbic acid magnesium)

Cat. No.: HY-103701A Assay: 99.13%
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L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

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L-Ascorbic acid 2-phosphate magnesium Chemical Structure

L-Ascorbic acid 2-phosphate magnesium Chemical Structure

CAS No. : 113170-55-1

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Ascorbic acid 2-phosphate magnesium:

L-Ascorbic acid 2-phosphate magnesium Related Antibodies

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1 Publications Citing Use of MCE L-Ascorbic acid 2-phosphate magnesium

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Description

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1].
L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ascorbic acid 2-phosphate magnesium Related Antibodies

Cell Viability Assay[1]

Cell Line: Human corneal endothelial cells (HCECs) 
Concentration: 0.1 mM; 0.3 mM; 1.5 mM
Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days
Result: Stimulated HCEC cells growth.
Molecular Weight

292.56

Formula

C6H9O9P.3/2Mg
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H](O1)[C@H](C[O-])O)=C(OP([O-])([O-])=O)C1=O.[1.5].[Mg+2]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (85.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4181 mL 17.0905 mL 34.1810 mL
5 mM 0.6836 mL 3.4181 mL 6.8362 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.13%

COA (255 KB) HNMR (125 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.4181 mL 17.0905 mL 34.1810 mL 85.4526 mL
5 mM 0.6836 mL 3.4181 mL 6.8362 mL 17.0905 mL
10 mM 0.3418 mL 1.7091 mL 3.4181 mL 8.5453 mL
15 mM 0.2279 mL 1.1394 mL 2.2787 mL 5.6968 mL
20 mM 0.1709 mL 0.8545 mL 1.7091 mL 4.2726 mL
25 mM 0.1367 mL 0.6836 mL 1.3672 mL 3.4181 mL
30 mM 0.1139 mL 0.5697 mL 1.1394 mL 2.8484 mL
40 mM 0.0855 mL 0.4273 mL 0.8545 mL 2.1363 mL
50 mM 0.0684 mL 0.3418 mL 0.6836 mL 1.7091 mL
60 mM 0.0570 mL 0.2848 mL 0.5697 mL 1.4242 mL
80 mM 0.0427 mL 0.2136 mL 0.4273 mL 1.0682 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Ascorbic acid 2-phosphate magnesium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ascorbic acid 2-phosphate113170-55-12-Phospho-L-ascorbic acidPhosphataseReactive Oxygen SpeciesEndogenous MetabolitehASCosteogenicdifferentiationmediumsupplementrunx2AvitaminCderivativeInhibitorinhibitorinhibit

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