L-Lysine-d₄ hydrochloride

Name: L-Lysine-d 4 hydrochloride
Brand: MedChemExpress
SKU: HY-N0470S6
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0470S6 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Lysine-d₄ (hydrochloride) is the deuterium labeled L-Lysine. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

For research use only. We do not sell to patients.

L-Lysine-d<sub>4</sub> hydrochloride Chemical Structure

L-Lysine-d₄ hydrochloride Chemical Structure

CAS No. : 284664-96-6

Size	Price	Stock	Quantity
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Lysine-d₄ hydrochloride:

L-Lysine hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

186.67

Formula

C₆H₁₁D₄ClN₂O₂

CAS No.

284664-96-6

Appearance

Solid

Color

White to off-white

SMILES

NCC([2H])([2H])C([2H])([2H])C[C@H](N)C(O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (267.85 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3570 mL	26.7852 mL	53.5705 mL
5 mM	1.0714 mL	5.3570 mL	10.7141 mL
10 mM	0.5357 mL	2.6785 mL	5.3570 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Al-Malki AL, et al. Suppression of acute pancreatitis by L-lysinein mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]

[3]. Baruffol C, et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats. Neurogastroenterol Motil. 2014 Jul;26(7):999-1009. [Content Brief]

[4]. Shimomura A, et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.3570 mL	26.7852 mL	53.5705 mL	133.9262 mL
	5 mM	1.0714 mL	5.3570 mL	10.7141 mL	26.7852 mL
	10 mM	0.5357 mL	2.6785 mL	5.3570 mL	13.3926 mL
	15 mM	0.3571 mL	1.7857 mL	3.5714 mL	8.9284 mL
	20 mM	0.2679 mL	1.3393 mL	2.6785 mL	6.6963 mL
	25 mM	0.2143 mL	1.0714 mL	2.1428 mL	5.3570 mL
	30 mM	0.1786 mL	0.8928 mL	1.7857 mL	4.4642 mL
	40 mM	0.1339 mL	0.6696 mL	1.3393 mL	3.3482 mL
	50 mM	0.1071 mL	0.5357 mL	1.0714 mL	2.6785 mL
	60 mM	0.0893 mL	0.4464 mL	0.8928 mL	2.2321 mL
	80 mM	0.0670 mL	0.3348 mL	0.6696 mL	1.6741 mL
	100 mM	0.0536 mL	0.2679 mL	0.5357 mL	1.3393 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.