1. Protein Tyrosine Kinase/RTK
  2. Src

Lck Inhibitor 

Cat. No.: HY-12072 Purity: 98.29%
Data Sheet SDS Handling Instructions

Lck Inhibitor is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM.

For research use only. We do not sell to patients.
Lck Inhibitor Chemical Structure

Lck Inhibitor Chemical Structure

CAS No. : 847950-09-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $138 In-stock
5 mg $118 In-stock
10 mg $188 In-stock
50 mg $756 In-stock
100 mg $1430 In-stock
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500 mg   Get quote  

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Other Forms of Lck Inhibitor:

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  • References

Description

Lck Inhibitor is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM. IC50 Value: 7 nM [1] Target: Lck in vitro: Lck Inhibitor (compound 25) exhibited good potency in the T-cell receptor-induced IL-2 secretion assay (IL- 2) and also inhibited subsequent T-cell proliferation (T-cell prolif.) in the same human T -cells. in vivo: A once daily dose of 25was administered orally at 10, 30, and 60 mg/kg from day 9 today 17. Paw volume was measured daily from day 9 through day 18. The compound showed a dose-dependent inhibition of arthritis, with an ED50 estimated at 24 mg/kg (Figure 6). Based on the measured plasma levels from the three dose groups, the exposure of 25 at the ED50 was estimated to be 2.7 μM·h (Cmax≈ 0.7 μM) [1]. Clinical trial: N/A

References
Molecular Weight

530.62

Formula

C₃₁H₃₀N₈O

CAS No.

847950-09-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Lck Inhibitor
Cat. No.:
HY-12072
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