LDN-211904 oxalate

Cat. No.: HY-107460 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC₅₀ of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC.

For research use only. We do not sell to patients.

LDN-211904 oxalate Chemical Structure

CAS No. : 1198408-78-4

Size	Price	Stock	Quantity
1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC₅₀: 0.079 µM (EphB3)^[1]

Molecular Weight

444.87

Formula

C₂₁H₂₁ClN₄O₅

CAS No.

1198408-78-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(O)=O)O.O=C(C1=CN=C2C=CC(C3CCNCC3)=CN21)NC4=C(Cl)C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (44.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2478 mL	11.2392 mL	22.4785 mL
5 mM	0.4496 mL	2.2478 mL	4.4957 mL
10 mM	0.2248 mL	1.1239 mL	2.2478 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (272 KB) SDS (0 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Qiao L, et al. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6122-6. [Content Brief]

[2]. Park SH, et al. Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer. Theranostics. 2019 Apr 12;9(8):2235-2251. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2478 mL	11.2392 mL	22.4785 mL	56.1962 mL
	5 mM	0.4496 mL	2.2478 mL	4.4957 mL	11.2392 mL
	10 mM	0.2248 mL	1.1239 mL	2.2478 mL	5.6196 mL
	15 mM	0.1499 mL	0.7493 mL	1.4986 mL	3.7464 mL
	20 mM	0.1124 mL	0.5620 mL	1.1239 mL	2.8098 mL
	25 mM	0.0899 mL	0.4496 mL	0.8991 mL	2.2478 mL
	30 mM	0.0749 mL	0.3746 mL	0.7493 mL	1.8732 mL
	40 mM	0.0562 mL	0.2810 mL	0.5620 mL	1.4049 mL