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  4. MB076

MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with Ki values ＜ 1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(−) susceptibility.

For research use only. We do not sell to patients.

MB076 Chemical Structure

MB076 Chemical Structure

CAS No. : 2832966-95-5

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MB076 Related Antibodies

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Description

MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with Ki values ＜ 1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(−) susceptibility[1].

IC50 & Target

Ki Target: ADC-7, ADC-30, ADC-162, ADC-33, ADC-219, ADC-212[1]
Ki: 0.21±0.016 μM (ADC-7), 0.058±0.005μM (ADC-30), 0.79±0.039μM (ADC-162), 0.10±0.004μM (ADC-33), 0.11±0.019 (ADC-219), 0.61±0.038μM (ADC-212)[1]
In Vitro

MB076 (compound B) (0.5-5 μM, 48 h) has an improved stability in human plasma[1].
MB076 (10 μg/mL, 48 h) acts synergistically in combination with Ceftazidime (CAZ, HY-B0593), and Cefotaxime (CTX, HY-A0088A) to restore pBCSK(−) susceptibility[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MB076 Related Antibodies

Cell Viability Assay[1]

Cell Line: Human Plasma
Concentration: 0.5 μM, 1 μM, 2.5 μM, 4 μM, 5 μM
Incubation Time: 48 h
Result: Showed excellent stability in human plasma, with a t1/2 value of 29 h, notably higher than the value obtained for ADC-7/S02030 (PDB4U0X) (9 h).
Molecular Weight

373.18

Formula

C9H12BN7O5S2
CAS No.
SMILES

NC1=NN=C(SCC(N[C@H](B(O)O)CN2C=C(C(O)=O)N=N2)=O)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MB076 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MB0762832966-95-5MB 076MB-076OthersInhibitorinhibitorinhibit

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HY-155011
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