The Comparative In Vitro Activity of FK-037 (Cefoselis), a New Broad-Spectrum Cephalosporin

FK-037, a new parenteral cephalosporin, was active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. The activity of FK---037 was similar to that of cefpirome and cefepime and generally superior to that of ceftazidime. Methicillin-resistant staphylococci were less susceptible than methicillin-sensitive isolates but most remained within the sensitive range. All streptococci and Enterobacteriaceae were sensitive as were the majority of isolates of Acinetobacter spp. and Pseudomonas aeruginosa. There was resistance amongst other non-fermentative gram-negative bacilli but this was species specific and most pseudomonads were sensitive, with resistance seen in Stenotrophomonas maltophilia, Alcaligenes spp. and Flavobacterium spp.