2. Academic Validation
  3. Structure-based design of protein tyrosine phosphatase-1B inhibitors

Structure-based design of protein tyrosine phosphatase-1B inhibitors

  • Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. doi: 10.1016/j.bmcl.2005.03.068.
Emma Black 1,  Jason Breed,  Alexander L Breeze,  Kevin Embrey,  Robert Garcia,  Thomas W Gero,  Linda Godfrey,  Peter W Kenny,  Andrew D Morley,  Claire A Minshull,  Andrew D Pannifer,  Jon Read,  Amanda Rees,  Daniel J Russell,  Dorin Toader,  Julie Tucker
Affiliations

Affiliation

  • 1 AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
PMID: 15863305 DOI: 10.1016/j.bmcl.2005.03.068
Abstract

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.

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