2. Academic Validation
  3. Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application

Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application

  • J Med Chem. 2006 Apr 20;49(8):2363-6. doi: 10.1021/jm060112m.
Giorgio Cozza 1,  Paolo Bonvini,  Elisa Zorzi,  Giorgia Poletto,  Mario A Pagano,  Stefania Sarno,  Arianna Donella-Deana,  Giuseppe Zagotto,  Angelo Rosolen,  Lorenzo A Pinna,  Flavio Meggio,  Stefano Moro
Affiliations

Affiliation

  • 1 Molecular Modeling Section, Dipartimento di Scienze Farmaceutiche, Università di Padova, via Marzolo 5, Padua, Italy.
PMID: 16610779 DOI: 10.1021/jm060112m
Abstract

Casein Kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and Other Diseases. Using a virtual screening approach, we have identified the ellagic acid, a naturally occurring tannic acid derivative, as a novel potent CK2 Inhibitor. At present, ellagic acid represents the most potent known CK2 Inhibitor (K(i) = 20 nM).

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