2. Academic Validation
  3. In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis

  • Antimicrob Agents Chemother. 2007 Mar;51(3):1105-6. doi: 10.1128/AAC.01310-06.
Poonpilas Hongmanee 1,  Kamolchanok Rukseree,  Benjamas Buabut,  Boontiwa Somsri,  Prasit Palittapongarnpim
Affiliations

Affiliation

  • 1 Division of Microbiology, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. [email protected]
PMID: 17178795 DOI: 10.1128/AAC.01310-06
Abstract

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.

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