2. Academic Validation
  3. Pinning down the polo-box domain

Pinning down the polo-box domain

  • Chem Biol. 2008 May;15(5):415-6. doi: 10.1016/j.chembiol.2008.04.009.
Kyung S Lee 1,  Jeffrey R Idle
Affiliations

Affiliation

  • 1 Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. [email protected]
PMID: 18482691 DOI: 10.1016/j.chembiol.2008.04.009
Abstract

Polo-like kinase 1 (PLK1) appears to be an attractive target for Anticancer therapy. In this issue of Chemistry & Biology, Reindl et al. (2008) describe the identification of a small molecule called Poloxin that appears to interfere with the function of the polo-box domain (PBD) of PLK1.

Figures
Products