2. Academic Validation
  3. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

  • Nat Chem Biol. 2011 Apr 13;7(7):428-30. doi: 10.1038/nchembio.573.
Philip M Reaper 1,  Matthew R Griffiths,  Joanna M Long,  Jean-Damien Charrier,  Somhairle Maccormick,  Peter A Charlton,  Julian M C Golec,  John R Pollard
Affiliations

Affiliation

  • 1 Vertex Pharmaceuticals (Europe), Abingdon, Oxfordshire, UK.
PMID: 21490603 DOI: 10.1038/nchembio.573
Abstract

Here we report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and the ATM-p53 tumor suppressor pathway in cells treated with DNA-damaging agents and establish ATR inhibition as a way to transform the outcome for patients with Cancer treated with ionizing radiation or genotoxic drugs.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-14731
    98.32%, ATM/ATR Inhibitor