2. Academic Validation
  3. Structure identification of Euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway

Structure identification of Euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway

  • Molecules. 2011 Apr 15;16(4):3222-31. doi: 10.3390/molecules16043222.
Jian-Ye Zhang 1,  Yong-Ju Liang,  Hu-Biao Chen,  Li-Sheng Zheng,  Yan-Jun Mi,  Fang Wang,  Xiao-Qin Zhao,  Xiao-Kun Wang,  Hui Zhang,  Li-Wu Fu
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, School of Basic Science, Guangzhou Medical College, Guangzhou 510182, China. [email protected]
PMID: 21499222 DOI: 10.3390/molecules16043222
Abstract

In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane Diterpenoids isolated from Caper Euphorbia Seed. Its Anticancer activity in vitro against lung Cancer A549 cells was also investigated and the IC(50) values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce Apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.

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