2. Academic Validation
  3. Structural determination of NSC 670224, synthesis of analogues and biological evaluation

Structural determination of NSC 670224, synthesis of analogues and biological evaluation

  • ChemMedChem. 2012 May;7(5):761-5. doi: 10.1002/cmdc.201200038.
Nathaniel B Zuckerman 1,  Andrew S Myers,  Tiffani K Quan,  Walter M Bray,  R Scott Lokey,  Grant A Hartzog,  Joseph P Konopelski
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, University of California, Santa Cruz (UCSC), Santa Cruz, CA 95064, USA.
PMID: 22378491 DOI: 10.1002/cmdc.201200038
Abstract

Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast Cancer drug. The structure of NSC 670224, previously thought to be a 2,4-dichloro arene, was established as the 3,4-dichloro arene, and a focused library of analogues were synthesized and biologically evaluated.

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