2. Academic Validation
  3. Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species

Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species

  • Org Lett. 2014 Oct 17;16(20):5366-9. doi: 10.1021/ol502572g.
Wen Bo Han 1,  Yan Hua Lu,  Ai Hua Zhang,  Gao Fei Zhang,  Ya Ning Mei,  Nan Jiang,  Xinxiang Lei,  Yong Chun Song,  Seik Weng Ng,  Ren Xiang Tan
Affiliations

Affiliation

  • 1 Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093, China.
PMID: 25286294 DOI: 10.1021/ol502572g
Abstract

The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively Antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.

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