2. Academic Validation
  3. Antiproliferative activity of synthetic fatty acid amides from renewable resources

Antiproliferative activity of synthetic fatty acid amides from renewable resources

  • Bioorg Med Chem. 2015 Jan 15;23(2):340-7. doi: 10.1016/j.bmc.2014.11.019.
Daiane S dos Santos 1,  Luciana A Piovesan 1,  Caroline R Montes D'Oca 1,  Carolina R Lopes Hack 1,  Tamara G M Treptow 1,  Marieli O Rodrigues 1,  Débora B Vendramini-Costa 2,  Ana Lucia T G Ruiz 2,  João Ernesto de Carvalho 2,  Marcelo G Montes D'Oca 3
Affiliations

Affiliations

  • 1 Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
  • 2 Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Unicamp, Campinas, SP, Brazil.
  • 3 Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil. Electronic address: [email protected].
PMID: 25510639 DOI: 10.1016/j.bmc.2014.11.019
Abstract

In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven Cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian Cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS Cancer.

Keywords

Glioma; Multidrug resistance; Ovarian cancer; Ricinoleic acid.

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