2. Academic Validation
  3. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice

4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice

  • Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24. doi: 10.1016/j.mrgentox.2016.05.009.
Claudia Rodrigues Berno 1,  Barbara de Toledo Rós 1,  Ingridhy Ostaciana Maia Freitas da Silveira 2,  Henrique Rodrigues Coelho 3,  Andréia Conceição Milan Brochado Antoniolli 4,  Adilson Beatriz 5,  Dênis Pires de Lima 5,  Antônio Carlos Duenhas Monreal 6,  Fabricio Garmus Sousa 6,  Roberto da Silva Gomes 7,  Rodrigo Juliano Oliveira 8
Affiliations

Affiliations

  • 1 Center for Stem Cells, Cell Therapy and Genetic Toxicology Studies, Maria Aparecida Pedrossian University Hospital, EBSERH, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Pharmacy, Center for Biological and Health Sciences, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 2 Postgraduate Program in Chemistry, Institute of Chemistry, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 3 Postgraduate Program in Health and Development in the Midwestern Region, Medical School, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 4 Center for Stem Cells, Cell Therapy and Genetic Toxicology Studies, Maria Aparecida Pedrossian University Hospital, EBSERH, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Health and Development in the Midwestern Region, Medical School, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 5 Postgraduate Program in Pharmacy, Center for Biological and Health Sciences, UFMS, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Chemistry, Institute of Chemistry, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 6 Postgraduate Program in Pharmacy, Center for Biological and Health Sciences, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 7 Postgraduate Program in Chemistry, Institute of Chemistry, UFMS, Campo Grande, Mato Grosso do Sul, Brazil; College of Sciences and Technology (FACET), Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil.
  • 8 Center for Stem Cells, Cell Therapy and Genetic Toxicology Studies, Maria Aparecida Pedrossian University Hospital, EBSERH, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Pharmacy, Center for Biological and Health Sciences, UFMS, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Health and Development in the Midwestern Region, Medical School, UFMS, Campo Grande, Mato Grosso do Sul, Brazil. Electronic address: [email protected].
PMID: 27402479 DOI: 10.1016/j.mrgentox.2016.05.009
Abstract

The analgesic drug dipyrone is used to treat side effects (including pain and fever) of Cancer chemotherapeutic agents. Dipyrone is metabolized to 4-aminoantipyrine (4-AA), a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). We evaluated the genotoxic, mutagenic, apoptotic, and immunomodulatory activities of 4-AA in vivo and the effects of its combination with the antineoplastic drugs doxorubicin, cisplatin, and cyclophosphamide. 4-AA did not cause genotoxic/mutagenic damage, splenic phagocytosis, or leukocyte alterations. However, when combined with the antineoplastic agents, 4-AA decreased their genotoxic, mutagenic, apoptotic, and phagocytic effects. These results suggest that 4-AA might interfere with DNA damage-mediated chemotherapy.

Keywords

4-aminoantipyrine; DNA damage; cancer; dipyrone; immunomodulatory effect.

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