2. Academic Validation
  3. Sphingosine-1-phosphate receptors and innate immunity

Sphingosine-1-phosphate receptors and innate immunity

  • Cell Microbiol. 2018 May;20(5):e12836. doi: 10.1111/cmi.12836.
Arielle M Bryan 1,  Maurizio Del Poeta 1 2 3
Affiliations

Affiliations

  • 1 Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, USA.
  • 2 Veterans Administration Medical Center, Northport, NY, USA.
  • 3 Division of Infectious Diseases, Stony Brook University, Stony Brook, NY, USA.
PMID: 29498184 DOI: 10.1111/cmi.12836
Abstract

Sphingosine-1-phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. One well-studied role of S1P signalling is to modulate T-cell trafficking, which has a major impact on adaptive immunity. Compounds that target S1P signalling pathways are of interest for immune system modulation. Recent studies suggest that S1P signalling regulates many more cell types and processes than previously appreciated. This review will summarise current understanding of S1P signalling, focusing on recent novel findings in the roles of S1P receptors in innate immunity.

Keywords

G protein coupled receptors; Inhibitors; Innate immunity; S1P receptors; Sphingolipid; Sphingosine-1-phosphate.

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