2. Academic Validation
  3. A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength

A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength

  • Chem Commun (Camb). 2019 Jan 29;55(10):1502-1505. doi: 10.1039/c8cc08879a.
Liangwei Zhang 1,  Shoujiao Peng,  Jinyu Sun,  Ruijuan Liu,  Shudi Liu,  Jianguo Fang
Affiliations

Affiliation

  • 1 State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. [email protected].
PMID: 30648177 DOI: 10.1039/c8cc08879a
Abstract

A ratiometric fluorescent probe of methionine sulfoxide reductase, Msr-Ratio, was disclosed for monitoring the Enzyme activity in vitro and in live cells. The probe displayed favorable properties such as a nearly 400-fold fluorescence change, fast response rate (<30 min), large Stokes shift (120 nm), and green emission (550 nm).

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