2. Academic Validation
  3. A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

  • Cell Rep. 2020 Oct 20;33(3):108284. doi: 10.1016/j.celrep.2020.108284.
Lingli He 1,  Liang Yuan 2,  Wentao Yu 1,  Yang Sun 1,  Dan Jiang 1,  Xiaodong Wang 2,  Xue Feng 1,  Zuoyun Wang 1,  Jinjin Xu 1,  Ruizeng Yang 1,  Wenxiang Zhang 1,  Hua Feng 3,  Hang-Zi Chen 4,  Yi Arial Zeng 1,  Lijian Hui 1,  Qiao Wu 4,  Yonglong Zhang 5,  Lei Zhang 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
  • 2 School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • 3 Omics Core of Bio-Med Big Data Center, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • 4 State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, China.
  • 5 State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: [email protected].
  • 6 State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Suzhou 215121, China. Electronic address: [email protected].
PMID: 33086070 DOI: 10.1016/j.celrep.2020.108284
Abstract

The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and Apoptosis. How this pathway triggers cell Apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hippo pathway whereby YAP regulates the transcription, phosphorylation, and mitochondrial localization of NR4A1. NR4A1, in turn, functions as a feedback inhibitor of YAP to promote its degradation, thereby inhibiting the function of YAP during liver regeneration and tumorigenesis. Our studies elucidate a regulatory loop between NR4A1 and YAP to coordinate Hippo signaling activity during liver regeneration and tumorigenesis and highlight NR4A1 as a marker of Hippo signaling, as well as a therapeutic target for hepatocellular carcinoma.

Keywords

Hippo signaling pathway; NR4A1; apoptosis; hepatocellular carcinoma (HCC); liver regeneration.

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