2. Academic Validation
  3. Bassiamide A, a new alkaloid from xero-halophyte Bassia indica Wight

Bassiamide A, a new alkaloid from xero-halophyte Bassia indica Wight

  • Nat Prod Res. 2022 Jul;36(14):3610-3618. doi: 10.1080/14786419.2021.1872572.
Ahmed Othman 1 2,  Yhiya Amen 1 3,  Masako Matsumoto 1,  Maki Nagata 1,  Kuniyoshi Shimizu 1
Affiliations

Affiliations

  • 1 Department of Agro-environmental Sciences, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
  • 2 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
  • 3 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
PMID: 33459047 DOI: 10.1080/14786419.2021.1872572
Abstract

N-[(3-(3-methyl-1-oxo-butyl)amino)propyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide (7), named 'Bassiamide A', a new alkaloid, together with six known compounds including one lignan (1) and five lignanamides (2-6), were isolated from the aerial parts of Bassia indica Wight. The study also reported an optimal separation of a rare occurring R-isomer lignanamide derivative (6) from a natural origin, in addition to its known corresponding S-isomer (5). Structures of isolated compounds were elucidated based on NMR spectroscopic data, HR-MS, and comparison with known related ones, and they were identified as syringaresinol (1), N-trans-feruloyl-3-methoxytyramine (2), N-trans-feruloyltyramine (3), S-(-)-N-trans-feruloyl normetanephrine (4), S-(-)-N-trans-feruloyl octopamine (5), R-(+)-N-trans-feruloyl octopamine (6). The isolated compounds were evaluated for their anti-acetylcholinesterase activity, and they showed weak inhibitory activity.

Keywords

Alkaloids; Bassia indica; Chenopodiaceae; anticholinesterase; halophytes; lignanamides.

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