2. Academic Validation
  3. Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources

Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources

  • Commun Biol. 2021 Oct 7;4(1):1161. doi: 10.1038/s42003-021-02689-8.
Viktoria E Stromsky # 1,  Melika Hajkazemian # 1,  Elizabeth Vaisbourd 1,  Raimondas Mozūraitis 2 3,  S Noushin Emami 4 5 6
Affiliations

Affiliations

  • 1 Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  • 2 Laboratory of Chemical and Behavioural Ecology, Institute of Ecology, Nature Research Centre, Vilnius, Lithuania.
  • 3 Department of Zoology, Stockholm University, Stockholm, Sweden.
  • 4 Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. [email protected].
  • 5 Molecular Attraction AB, Elektravägen 10, 126 30 Hägersten, Stockholm, Sweden. [email protected].
  • 6 Natural Resources Institute, FES, University of Greenwich, London, UK. [email protected].
  • # Contributed equally.
PMID: 34620990 DOI: 10.1038/s42003-021-02689-8
Abstract

Recent data show that parasites manipulate the physiology of mosquitoes and human hosts to increase the probability of transmission. Here, we investigate phagostimulant activity of Plasmodium-metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), in the primary vectors of multiple human diseases, Anopheles coluzzii, An. arabiensis, An. gambiae s.s., Aedes aegypti, and Culex pipiens/Culex torrentium complex species. The addition of 10 µM HMBPP to blood meals significantly increased feeding in all the species investigated. Moreover, HMBPP also exhibited a phagostimulant property in plant-based-artificial-feeding-solution made of beetroot juice adjusted to neutral pH similar to that of blood. The addition of AlbuMAXTM as a lipid/protein source significantly improved the feeding rate of An. gambiae s.l. females providing optimised plant-based-artificial-feeding-solution for delivery toxins to control vector populations. Among natural and synthetic toxins tested, only fipronil sulfone did not reduce feeding. Overall, the toxic-plant-based-artificial-feeding-solution showed potential as an effector in environmentally friendly vector-control strategies.

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