2. Academic Validation
  3. 7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production

7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production

  • Sci Rep. 2022 May 24;12(1):8760. doi: 10.1038/s41598-022-12695-3.
Hao Dong 1,  Chenjie Feng 1,  Xiyunyi Cai 2,  Yuanyuan Hao 1,  Xinyue Gu 3,  Lei Cai 4,  Shuting Wu 5,  Jiamin Chen 1,  Zhou Liu 5,  Wen Xie 1,  Xuanren Lu 5,  Hongfa Qian 1,  Yulin Liu 1,  Yiming Cao 1,  Junlin Zhu 1,  Jiayi Xu 1,  Yanjie Zhou 1,  Shuangyu Ma 5,  Sha Yang 1,  Yufeng Shi 1,  Haojiang Yu 1,  Minjie Shi 1,  Yurong Wang 6,  Harvest F Gu 6,  Lei Fan 7,  Liang Wu 8
Affiliations

Affiliations

  • 1 Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 2 School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 3 Department of Applied Mathematics and Statistics, The Johns Hopkins University, Baltimore, MD, 21218, USA.
  • 4 School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 5 School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 6 School of Basic Medicine and Clinical Pharmacy, Center for Pathophysiology, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 7 Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210009, People's Republic of China. [email protected].
  • 8 Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. [email protected].
PMID: 35610286 DOI: 10.1038/s41598-022-12695-3
Abstract

7-Met, a derivative of soybean isoflavone, is a natural flavonoid compound that has been reported to have multiple signaling pathways regulation effects. This study investigated the therapeutic effects of 7-Met on mice with atopic dermatitis induced by fluorescein isothiocyanate (FITC), or oxazolone (OXZ). 7-Met ameliorated FITC or OXZ-induced atopic dermatitis symptoms by decreasing ear thickness, spleen index, mast cell activation, neutrophil infiltration and serum IgE levels in female BALB/c mice. In FITC-induced atopic dermatitis mice, 7-Met reduced Th1 cytokines production and regulated Th1/Th2 balance by downregulating the secretion of thymic stromal lymphopoietin (TSLP) via inactivation of the NF-κB pathway. In OXZ-induced atopic dermatitis, 7-Met functioned through the reduction of Th17 cytokine production. Our study showed that 7-Methoxyisoflavone alleviated atopic dermatitis by regulating multiple signaling pathways and downregulating chemokine production.

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