2. Academic Validation
  3. Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells

Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells

  • Endocrines. 2022 Dec;3(4):813-820. doi: 10.3390/endocrines3040067.
Khadeja-Tul Kubra 1,  Mohammad S Akhter 1,  Kaitlyn Apperley 1,  Nektarios Barabutis 1
Affiliations

Affiliation

  • 1 School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.
PMID: 36540765 DOI: 10.3390/endocrines3040067
Abstract

Growth hormone-releasing hormone (GHRH) and its receptors are expressed in a variety of human cancers, and have been involved in malignancies. GHRH antagonists (GHRHAnt) were developed to suppress tumor progression and metastasis. Previous studies demonstrate the involvement of Reactive Oxygen Species (ROS) in Cancer progression. Herein, we investigate the effect of a commercially available GHRH antagonist, namely JV-1-36, in the redox status of the A549 human Cancer cell line. Our results suggest that this peptide significantly reduces ROS production in those cells in a time-dependent manner and counteracts H2O2-induced ROS. Our study supports the anti-oxidative effects of JV-1-36 and contributes in our knowledge towards the in vitro effects of GHRHAnt in cancers.

Keywords

endothelium; inflammation; lung injury; oxidative stress.

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