2. Academic Validation
  3. Biomimetic Biomembrane Encapsulation and Targeted Delivery of a Nitric Oxide Release Platform for Therapy of Parkinson's Disease

Biomimetic Biomembrane Encapsulation and Targeted Delivery of a Nitric Oxide Release Platform for Therapy of Parkinson's Disease

  • ACS Biomater Sci Eng. 2023 Apr 11. doi: 10.1021/acsbiomaterials.3c00146.
Zhixin Huang 1 2,  Binbin Hu 2 3,  Bohan Xiang 2,  Huaqiang Fang 2 4,  Bingzhen Zhang 1,  Ying Wang 2,  Yi Zhuo 2,  Dan Deng 1 2,  Xiaolei Wang 1 2
Affiliations

Affiliations

  • 1 School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330088, Jiangxi, P. R. China.
  • 2 The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang 330088, Jiangxi, P. R. China.
  • 3 The Department of Internal Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P. R. China.
  • 4 The Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P. R. China.
PMID: 37040524 DOI: 10.1021/acsbiomaterials.3c00146
Abstract

The existence of the blood-brain barrier (BBB) and the complex inflammatory environment in the brain are two major obstacles in the treatment of Parkinson's disease (PD). As a target group, we modified the red blood cell membrane (RBCM) on the surface of upconversion nanoparticles (UCNPs) in this study to effectively target the brain. Mesoporous silicon, coated with UCNPs (UCM), was loaded with S-nitrosoglutathione (GSNO) as the nitric oxide (NO) donor. Then, UCNPs were excited to emit green LIGHT (540 nm) by 980 nm near-infrared (NIR). In addition, it produced a light-responsive anti-inflammatory effect by promoting the release of NO from GSNO and lowering the brain's level of proinflammatory factors. A series of experiments demonstrated that this strategy could effectively mitigate the inflammatory response damage of neurons in the brain.

Keywords

980 nm NIR; Parkinson’s disease; nitric oxide; upconversion.

Figures
Products